Perimenopause

Perimenopause is an important period in a woman’s life that often goes unnoticed. But the changes in the body that occur during this time can affect your health and well-being. Ignoring symptoms such as hot flashes, fatigue, or cycle irregularities can have serious consequences. Understanding the causes, symptoms, and possible solutions is the first step to maintaining your health and quality of life.

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What is perimenopause?

Perimenopause is the period that precedes menopause and usually begins in women after 40 years of age. This time is characterized by a gradual decrease in the levels of female hormones - estrogen and progesterone, which leads to changes in the functioning of the reproductive system.

Perimenopause can last from several months to 5-10 years. This stage ends when menstruation stops completely, which is the beginning of menopause.

Why is it important to pay attention to this period? Changes occurring in the body can affect overall health. For example, a decrease in estrogen levels can increase the risk of osteoporosis, cardiovascular disease, and deterioration of the skin.

What is perimenopause?

Age of onset of perimenopause

Perimenopause usually begins in women between the ages of 40 and 50. However, the exact age can vary significantly depending on individual characteristics, heredity, and lifestyle.

If the first signs appear before the age of 40, this is called early perimenopause. Genetic factors, autoimmune diseases, or the effects of medical procedures (such as ovarian removal or chemotherapy) can contribute to the problem.

How to recognize the onset of perimenopause? Pay attention to changes in the menstrual cycle, the appearance of hot flashes, poor sleep, irritability, or vaginal dryness.

What influences the age at which perimenopause begins?

  • Genetics If women in your family (such as your mother or grandmother) experienced early perimenopause, there is a chance that you will too
  • Lifestyle Smoking, chronic stress, and excess weight can speed up the onset of hormonal changes
  • Reproductive health Early ovarian surgery, endometriosis, or other gynecological conditions can affect the age of onset
  • Environmental factors Bad habits and poor ecology can have a negative impact on the ovaries

Classification of premenopause

Premenopause is a period that can vary in age of onset, manifestations and their severity.

Criteria Type Description Additional comments
Age of onset Early perimenopause Onset before age 40. Can be caused by genetics, autoimmune diseases, or stress. It is important to exclude pathological causes such as premature ovarian failure.
Middle perimenopause Occurs in the age range of 40-50 years. This is the most common option. A normal physiological process, typical for most women.
Late perimenopause Occurs after 50 years. Associated with the genetic characteristics of the body. Less common, but usually does not require additional intervention.
Severity of symptoms Mild form Minor changes in the cycle, occasional hot flashes, mild mood changes. Usually does not require treatment, supportive therapy is sufficient.
Moderate form Regular hot flashes, sleep problems, irritability, cycle changes are more noticeable. Requires medical supervision to choose the appropriate correction.
Severe form Frequent hot flashes, severe sleep disturbances, irritability, depression, abrupt cycle changes. Medical care is needed, including hormone replacement therapy (HRT).
Hormonal status With normal hormone levels Estrogen levels remain within normal limits, cycle changes are minimal. The transition period is still in its initial stage, observation is usually sufficient.
With reduced hormone levels Estrogen levels decrease, hot flashes, vaginal dryness and other symptoms become more pronounced A doctor's consultation is necessary to select a treatment to reduce discomfort
Causes Physiological Natural decline in ovarian function with age. The most common scenario.
Artificial Occurs after surgical removal of the ovaries or their damage as a result of treatment (for example, chemotherapy). Requires special correction, as the signs may be more pronounced.
Premature Occurs as a result of pathologies (autoimmune diseases, genetic disorders). Requires a thorough examination and an individual approach to treatment.

Hormones in Premenopause

During the premenopause period, hormonal changes occur in a woman’s body.

Estrogens

Estrogens are the most important female sex hormones. In premenopause, their levels begin to decrease. This leads to changes in the menstrual cycle (it becomes irregular) and can cause symptoms such as hot flashes, vaginal dryness and mood changes. The decrease in estrogen also affects bone tissue, increasing the risk of osteoporosis.

Progesterone

Progesterone regulates the second phase of the menstrual cycle. In premenopause, its production decreases due to irregular ovulation. Progesterone deficiency can cause heavy and prolonged menstruation, as well as increase the risk of endometrial hyperplasia (excessive thickening of the uterine lining).

Follicle-stimulating hormone (FSH)

FSH is produced by the pituitary gland and regulates the functioning of the ovaries. In premenopause, FSH levels increase as the body tries to compensate for the decline in ovarian function. An FSH test is often used to confirm perimenopause.

Luteinizing Hormone (LH)

LH is involved in ovulation and the production of sex hormones. Like FSH, LH levels rise in an attempt to stimulate the ovaries, but their response is less pronounced.

Testosterone

Testosterone is a male sex hormone that is also present in women. Its levels typically decrease during perimenopause. This can contribute to decreased libido, energy, and muscle mass.

Thyroid Hormones

Thyroid hormones are not directly affected by perimenopause, but imbalances in them can exacerbate symptoms of perimenopause, such as fatigue, mood swings, and weight gain.
Endometrial Hyperplasia in Premenopause

Endometrial hyperplasia is a condition in which the inner lining of the uterus thickens due to hormonal imbalance. In premenopause, this is due to a lack of progesterone and excess estrogen. Symptoms include irregular periods, bleeding between periods, and discomfort in the lower abdomen. Sometimes the disease is asymptomatic, only detectable by ultrasound.

Without treatment, hyperplasia can progress, increasing the risk of cancer. The doctor selects treatment depending on the degree of hyperplasia. This may include hormonal therapy to restore hormonal balance or surgical methods if atypical changes in the tissues are suspected.

Uterine Myoma in Premenopause

Uterine myoma is a benign tumor that is more common in premenopausal women. Myoma growth is stimulated by high estrogen levels. The disease manifests itself in heavy menstruation, spotting, and a feeling of pressure in the lower abdomen. With large growths, it is possible to compress adjacent organs, which causes frequent urination or constipation.

Without treatment, the neoplasm can cause anemia due to blood loss and seriously reduce the quality of life. The doctor determines the treatment tactics depending on the size and symptoms. This may be hormonal therapy to stop growth or surgical removal of the nodes.

Postmenopausal ovarian cysts

Postmenopausal ovarian cysts require close attention, since the likelihood of malignant changes increases. They are usually discovered by chance during an ultrasound, since they often occur without symptoms. As the size of the cyst increases, it can cause pain, a feeling of pressure, or sharp pain when ruptured.

The danger of a cyst is the risk of its degeneration into a malignant tumor. The doctor prescribes treatment depending on the structure and size of the cyst. Simple lesions are observed, while complex or suspicious lesions are removed with subsequent histological examination of the tissue.

General information

Perimenopause Symptoms

Signs of disorders:

  • Irregular menstruation. Changes in intervals between cycles, missed periods, unstable bleeding intensity
  • Hot flashes. Sudden feeling of heat, accompanied by sweating, especially at night
  • Increased irritability and mood swings. Emotional instability, anxiety or depression
  • Sleep disturbances. Insomnia, frequent awakenings, feeling tired in the morning
  • Decreased libido. Vaginal dryness and discomfort during intimacy
  • Changes in appearance. Dry skin, brittle nails, hair loss, weight gain in the waist area
  • Feeling of discomfort in the pelvic area. Itching, vaginal dryness, increased risk of infections
  • Problems with memory and concentration. Difficulty remembering, decreased speed of thinking

If you notice symptoms of premenopause or want to control your hormonal balance, the doctors at the K+31 clinic will help you understand and choose the right treatment. Sign up for a consultation, call or write to us. For details and prices, please call or visit our website.

Causes of perimenopause

Causes of perimenopause in the body:

  • Age-related changes. Premenopause begins due to a natural decline in ovarian function. After 35-40 years, the number of eggs decreases, and the level of hormones such as estrogen and progesterone gradually decreases
  • Surgical interventions. Removal of the ovaries (oophorectomy) or uterus (hysterectomy) can lead to an early decrease in hormonal activity
  • Endocrine disorders. Thyroid disease, diabetes, and other hormonal imbalances can accelerate the onset of perimenopause
  • Chemo- and radiotherapy. Cancer treatment can damage the ovaries and reduce their function, which provokes early hormonal changes
  • Autoimmune diseases. Disorders in which the body attacks its own cells can affect the ovaries and cause their dysfunction
  • Vitamin and mineral deficiencies. A lack of vitamin D, iron or calcium can weaken the health of the reproductive system and affect hormonal levels

Bad habits are also a factor in the early development of premenopause.

"Smoking, constant stress, excess weight or, conversely, underweight can really speed up the onset of premenopause. Nicotine is especially harmful to the ovaries - it reduces their functionality, which leads to an earlier onset of hormonal changes." - a doctor at the K+31 clinic.

Diagnosing Premenopause

Diagnosing premenopause begins with an analysis of symptoms. The doctor clarifies complaints: cycle changes, hot flashes, mood swings or decreased libido. Information is collected on chronic diseases, heredity and possible hormonal disorders.

The following methods are used to confirm the diagnosis and exclude other conditions:

  • Blood tests for hormones. The level of FSH (follicle-stimulating hormone), LH (luteinizing hormone) and estrogens is assessed. Increased FSH with decreased estrogens indicates the onset of hormonal changes
  • Ultrasound of the pelvic organs. The study helps to assess the condition of the ovaries and endometrium, as well as exclude fibroids, cysts or hyperplasia
  • General and biochemical blood tests. Allows to exclude anemia or inflammatory processes

“A decrease in estrogen levels in premenopause can lead to thinning of bone tissue. If there is a risk of osteoporosis, we recommend undergoing densitometry. The study allows you to detect changes in bone density in time and prevent fractures.” – doctor of the clinic “K+31”.

Postmenopause Treatment

Different treatment approaches are available, which are selected individually.

Hormone Replacement Therapy (HRT)

Hormone replacement therapy helps to compensate for the lack of estrogens and progestins. It reduces symptoms such as hot flashes, vaginal dryness and mood swings. In addition, HRT reduces the risk of osteoporosis, which often develops due to hormone deficiency.

Therapy is prescribed strictly individually. The doctor takes into account the age, general health and the presence of contraindications, such as thrombosis or hormone-dependent tumors. Forms of drugs include tablets, patches, gels and vaginal suppositories.

Non-hormonal therapy

For women for whom hormonal therapy is contraindicated, non-hormonal drugs are prescribed. These include:

  • Phytoestrogens (natural analogues of estrogens). They help reduce hot flashes and night sweats
  • Calcium and vitamin D preparations. Such products strengthen bone tissue and prevent osteoporosis
  • Selective estrogen receptor modulators. They protect bones, but do not affect breast and uterine tissue

In addition, doctors recommend changing your lifestyle: increase physical activity, quit smoking, and include more calcium-rich foods in your diet.

Disease prevention

Disease prevention begins with regular health monitoring and following doctor's recommendations. The main goal is to reduce risks and prevent complications.

  • Regular medical examinations. Visit a gynecologist at least once a year, even if there are no complaints
  • Healthy lifestyle. A balanced diet, moderate physical activity and giving up bad habits strengthen the immune system and reduce the risk of developing diseases
  • Monitoring hormonal levels. This is especially important in premenopause and postmenopause. If necessary, the doctor may prescribe tests to assess hormone levels and recommendations for their correction
  • Avoiding stress. Chronic stress disrupts the hormonal system and reduces immunity. Try to find time for rest and activities that bring joy
  • Timely treatment of infections. Treat any inflammatory processes and infections so that they do not provoke complications

Discuss preventive measures with the doctors of the K+31 clinic. We will help you create an individual plan and answer all your questions.

Answers to popular questions

Premenopause is a period that raises many questions for many women. Answers to the most common ones will help to understand the nuances and remove possible doubts.

Is it possible to get pregnant during perimenopause?

Yes, pregnancy is possible, as ovulation may continue, although irregularly. If you are not planning a pregnancy, it is important to continue using contraception until your doctor confirms that you have entered menopause.

What are the contraindications for hormone therapy?

Hormonal therapy is not prescribed for oncological diseases (for example, breast cancer), thrombosis or thrombophilia, as well as for severe liver diseases. Before starting treatment, your doctor will definitely conduct an examination to exclude risks.

How do I know if my symptoms are related to perimenopause?

Some symptoms of perimenopause, such as mood swings, hot flashes, or sleep disturbances, may resemble other conditions (for example, stress or depression). To confirm the diagnosis, your doctor will conduct tests for hormone levels and exclude other causes of discomfort.

Do I need to change my diet during perimenopause?

Yes, it is worth adjusting my diet. Include more foods rich in calcium and vitamin D to strengthen your bones. Limit sugar, caffeine and fatty foods as they may worsen symptoms such as hot flashes or nervousness.

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