Lung and mediastinal cancer

Lung cancer

Lung cancer is a malignant tumor that develops from the lung parenchyma or bronchial tissues. This type of cancer is one of the most common cancers. It is characterized by early metastases and latent course, those. not accompanied by obvious symptoms. As a result, cancer is often detected already in stages 3 or 4. Therein lies its danger.

Risk factors for lung cancer

It is known that the main risk factor for developing lung cancer is the inhalation of carcinogens. Approximately 90% of detected cases are associated with smoking. More precisely, with the action of carcinogens contained in tobacco smoke. The risk increases in proportion to the duration of the smoker and the number of cigarettes he smokes. Those. it is higher the longer a person smokes and the more cigarettes (or packs of cigarettes) a day he smokes. For the smoker, the most effective way reduce the likelihood of developing the disease will be the rejection of addiction.

Not only smokers are at risk, but also those around them. Passive smoking is also a risk factor. So in a married couple, where one smokes and the other does not, for a non-smoker, the likelihood of lung cancer increases by 30%.

Smoking is the main cause of the disease, but not the only one. It is also caused by air pollution. Residents of industrial areas with processing and mining industries are 3-4 times more likely to get lung cancer than than people living in rural areas. Other risk factors include:

  • Radioactive exposure.
  • Old, untreated lung diseases such as tuberculosis, bronchitis, pneumonia, bronchiectasis.
  • Contact with certain substances: asbestos, arsenic, cadmium, nickel, radon, chloromethyl ether, chromium.

Symptoms of the disease

The clinical picture of lung cancer is "hidden" and non-specific, ie. characteristic of various diseases of the respiratory system. That is why, when they appear, many people are in no hurry to be examined. They underestimate the severity of the problem. At the initial stage of the development of the disease, there is increased fatigue, a slight decrease in working capacity, interest in life, and apathy. At But this should alert every person. Other symptoms include:

  • Difficulty breathing.
  • Cough that persists for a long time.
  • Pain or discomfort in the chest.
  • Progressive dyspnoea.
  • The appearance of sputum with blood.
  • Hoarse voice.
  • Decreased appetite.
  • Unrelated weight loss.
  • Progressive feeling of tiredness.
  • Swelling of the face or swelling of the veins in the neck.

How lung cancer is diagnosed

The main method for diagnosing lung cancer in oncology is computed tomography. When a neoplasm is detected in a patient, a number of additional studies are prescribed that will give an idea of the type of formation. If it turns out to be malignant, the type of cancer and its prevalence will be determined. Bronchoscopy plays an important role among additional diagnostic methods. With its help, it is possible, in some cases, to detect a protruding bronchial carcinoma, infiltration or compression of the walls of the bronchi.

During bronchoscopy, a thin and flexible tube is inserted into the patient's bronchus, at the end of which there is a lens. With its help, you can visually determine the presence or absence of cancer symptoms, as well as take a biopsy. The sample is needed for further analysis. If the case is not diagnostically clear, the attending physician may decide to resect a section of the lung, where malignant neoplasms are suspected. These methods provide reliable information about the presence tumor changes, their prevalence, stage of the disease. Based on these data, a cancer treatment regimen is selected.

Methods of treatment

In the treatment of lung cancer in oncology, the method surgical removal of the tumor is used, drug therapy (chemotherapy, targeted and immunotherapy), radiation therapy, as well as their various combinations. Choosing a specific method depends on the condition of the patient, the stage of the disease, the size of the neoplasm and other factors. The most effective treatment for cancer is surgery. During the operation, a part of the lung with a tumor or the entire lung with regional lymph nodes is removed. The outcome of the operation is affected by the location of the tumor and its size, patient age, presence of metastases.

The second most effective treatment for lung cancer is radiation therapy. At the same time, the tumor is affected using ionizing radiation. High efficiency due to the use of modern equipment (VARIAN linear accelerators with a 3D planning) and work in accordance with international standards. The method of chemotherapy consists in introducing drugs into the patient's body, selectively suppressing the growth of malignant cells. In this case, there is no serious damage to healthy organs and tissues.

Chemotherapy is the main treatment for tumors, advanced cases of lung cancer.

In recent years, in oncology, along with chemotherapy and targeted therapy, immunotherapy has actively entered the treatment of lung cancer. which actually revolutionized the treatment of patients with this serious illness. It is the immunotherapy significantly increase life expectancy and the order of every 6th patient can be cured in the last stage of lung cancer! In fact, chemotherapy without immunotherapy should not be used at present.

The choice in favor of surgical treatment of tumors is made in the early stages of oncological disease, with a localized tumor of a non-small cell form. But only if the patient's condition allows such an operation. At a later stage, the surgical method of removing the tumor is ineffective. Such cases are distinguished by the large size of the tumor, the presence of metastases in distant organs and regional lymph nodes. There is no surgical intervention and with small cell cancer. If surgery is contraindicated, chemotherapy and radiation therapy may help. Comprehensive cancer treatment, including all described above methods, is carried out if the patient's condition allows it.

Lung cancer prevention

Since smoking is the leading cause of lung cancer, the best prevention for non-smokers is not to acquire this dangerous habit, and for smokers to get rid of it. You also need to protect yourself as much as possible from other harmful influences, such as polluted, automobile and industrial emissions, air, household contact with radon, contact with industrial carcinogens. When smoking and other risk factors are combined, they mutually reinforce each other. Secondary prevention is also important, which includes annual screeningannual screening for people at high risk. They allow you to detect lung cancer at an early stage, when the disease is curable.

Mediastinal cancer

In oncology, mediastinal cancer refers to all malignant tumors of the mediastinum - that is, organs that are located in the chest cell in the cavity between the lungs. Such organs of the mediastinal region include: thymus (thymus gland), esophagus, trachea, heart, aorta and other blood vessels, lymph nodes, nerves. In another way, these tumors are called mediastinal tumors. In most cases they are benign. The presence of malignant neoplasms (when the patient is diagnosed with mediastinal cancer) occurs in 40% of cases.

The most common forms of mediastinal cancer: lymphoma, neuroblastoma, thymoma (thymus cancer), chondrosarcoma, angiosarcoma, dysgerminoma, osteoblastosarcoma, as well as metastases of melanoma, cancer of the lung, breast, esophagus, etc.

The causes of mediastinal tumors are not completely clear. It is assumed that risk factors are ionizing radiation, carcinogens, some viruses (HIV, Epstein-Barr, etc.). Tumors of the mediastinum are quite rare, but the occurrence of malignant neoplasms in the chest is weakly dependent on the age and sex of the patient, and they can develop from any tissues and organs of the mediastinum.

Classification

Mediastinal cancer is divided into:

  • primary - tumors of the mediastinum that have arisen in the tissues of the mediastinum itself or tissues that limit the mediastinum: neurogenic tumors, fibrosarcomas, lymphomas, thymomas, liposarcomas, etc.;
  • secondary - metastases of tumors of the mediastinum from neighboring organs of the chest.

According to the location of the tumor of the mediastinum in oncology, they are classified into: tumors of the anterior (germinogenic tumors, lymphoma, thymoma), central (lymphadenopathy, tumors of the esophagus or trachea) and posterior mediastinum (neurogenic tumors, lymphadenopathy).

Symptoms of the disease

Until the tumor of the mediastinum reaches a certain size, the oncological disease is asymptomatic, the clinical picture is not pronounced. Symptoms appear with the growth of the neoplasm. Malignant tumors of the mediastinum can grow quite quickly, and therefore the transition from an asymptomatic stage to a pronounced clinical picture may be short-lived.

Increasing, the neoplasm begins to put pressure on neighboring organs or grow into them, which can cause:

  • chest pain that radiates to the neck, shoulder blade, or shoulder;
  • shortness of breath if the tumor presses on the trachea and bronchi;
  • difficulty in passing food through the esophagus due to its compression;
  • blue of the face or heaviness in the head due to compression of the vein;
  • reddening of the face if the neoplasm presses on the nerves.

Other symptoms and manifestations of mediastinal cancer may include: cough, hoarseness, fever and sweating, chest pain, hypoglycemia, muscle weakness, pruritus, facial or neck veins, irregular heartbeat, weight loss, etc. .

The clinical picture depends on the location and nature of the mediastinal tumor (benign or malignant neoplasm) and growth rate.

How is mediastinal cancer diagnosed?

Imaging methods such as X-rays and CT scans of the chest can be used to detect mediastinal tumors. The X-ray method is the main one for determining mediastinal cancer. CT allows you to determine the localization of the tumor and the extent of its spread.

After visual detection of a neoplasm, for the final diagnosis, histological verification is carried out - a biopsy - transbronchial (collection of mediastinal tumor cells occurs through bronchoscopy) or transthoracic (collection is carried out using a chest puncture during ultrasound or CT).

For the diagnosis of mediastinal cancer, diagnostic operations such as mediastinoscopy and videothoracoscopy are also used, and other additional studies are carried out.

Methods of treatment

The method of treatment for mediastinal cancer depends on the location, origin, histological type and size of the mediastinal tumor. It could be:

  • Surgical treatment (removal) is a rather complicated procedure, given the close location of the vital organs of the mediastinum. Often performed after a course of chemotherapy or radiation therapy, or even after several courses of chemotherapy. Thymomas, neurogenic tumors of the mediastinum, are treated in this way.
  • Chemotherapy is often used as an adjuvant therapy to reduce the size of a mediastinal cancer before it is removed or to prevent recurrence after surgical removal. In some cases, chemotherapy is used as a supportive treatment for mediastinal cancer when surgery is not possible, to slow down the growth of cancer cells and alleviate the patient's condition. Chemotherapy is used to treat lymphomas and some other mediastinal cancers.
  • Ray those

Service record



Specialists

All specialists
Merkulov
Igor Alexandrovich

Deputy chief physician for oncology, oncologist

Doctor of Sciences, PhD

Lyadov
Konstantin Viktorovich

Academician, professor, Doctor of Sciences, PhD

Petrov
Dmitry Yurevich

Deputy chief physician for oncology, surgeon

PhD, Docent

Ershova
Ksenia Igorevna

Head of department, oncologist

PhD

Abashin
Sergey Yuryevich

Head of oncology projects, oncologist

Doctor of Sciences, PhD, professor

Rasner
Pavel Ilyich

Consultant in urology, urologist

Doctor of Sciences, PhD, professor

Malygin
Sergey Evgenyevich

Oncologist-mammologist, surgeon

Pshikhachev
Ahmed Mukhamedovich

Urologist, Oncologist

Doctor of Sciences, PhD

Shevchuk
Alexei Sergeyevich

Oncogynecology consultant, obstetrician-gynecologist

PhD

Chichkanova
Tatyana Vladimirovna

Oncologist-mammologist, radiologist

Katz
Ksenia Vladimirovna

Dermatovenerologist, oncologist

Udin
Oleg Ivanovich

Deputy chief physician for surgery, surgeon

PhD

Kogonia
Lali Mikhailovna

Chemotherapist

Doctor of Sciences, PhD

Ushenina
Maria Valerievna

Oncologist-chemotherapist

PhD

Volkova
Daria Mikhailovna

Head of the radiation therapy department

Gomov
Mikhail Alexandrovich

Consultant in oncogynecology, obstetrician-gynecologist

Grishin
Igor Igorevich

Obstetrician-gynecologist

Doctor of Sciences, PhD, professor

Achba
Maya Otarovna

Radiologist, ultrasound diagnostician, oncologist-mammologist

Dubinina
Yulia Nikolaevna

Head of the oncology department of antitumor drug therapy, oncologist, hematologist