Clostridial colitis or pseudomembranous enterocolitis is a severe inflammatory disease of the large intestine. It is caused by the bacterium Clostridium difficile (C. difficile), which is activated when the balance is disturbed. intestinal microflora, usually after taking antibiotics. Understanding the causes, symptoms, and treatments for this condition will help you avoid developing a colonic perforation.
Causes of disease
Clostridia are bacteria that are naturally present in the intestines of many people and animals. Under normal conditions, they coexist with other bacteria without causing any health problems. When the balance of the microflora of C. difficile is disturbed, they become active, begin to actively multiply and release toxins. They damage the intestinal mucosa and cause inflammation, leading to the development of clostridial colitis.
Influence of antibiotics on the intestinal microflora
Antibiotics are widely used in medicine to fight bacterial infections. Their action is aimed at the destruction of harmful microorganisms, but at the same time they also affect beneficial bacteria, leading to intestinal dysbacteriosis. This creates favorable conditions for active reproduction of C. difficile and possible development (code for pseudomembranous colitis according to ICD-10 - A04.7).
Additional risk factors
In addition to antibiotic treatment, there are other factors that can increase the risk of developing clostridial colitis. These include:
- Prolonged inpatient treatment.
- Old age.
- Recent abdominal surgery
- Weak immunity.
- Malignant tumors.
- Renal failure.
Sometimes the disease develops in patients with chronic obstructive pulmonary disease. Also a provoking factor is the use of H2-histamine receptor blockers and proton pump inhibitors.
Pseudomembranous colitis: symptoms
The symptoms of the disease may vary depending on its severity. Mild forms of pseudomembranous colitis are characterized by the following features:
- Diarrhea. The most common symptom in which the stools can be copious and watery, sometimes with mucus.
- Abdominal pain. Patients are concerned about cramping pain.
- Clostridia. Accompanied by fever, weakness, headache, nausea and vomiting.
If the disease progresses, additional symptoms may appear that continue even after antibiotics are stopped. These include:
- Antibiotic-associated yellow or green diarrhea.
- The presence of traces of mucus and blood in the feces.
- Metabolic disorders due to dehydration and water and electrolyte imbalance.
In addition, patients have weakness, rapid pulse, low blood pressure, as well as impaired muscle tone and paresthesia.
Features of a severe form of pseudomembranous enterocolitis:
- Rapid development. Symptoms develop faster, intoxication intensifies, abdominal pain becomes more intense, and blood in the feces appears from the first days of the disease.
- Complications. Pathological enlargement of the intestine (megacolon) may occur, leading to rupture of the intestine and the development of peritonitis.
Antibiotic-associated colitis (clostridium ramosum) requires immediate treatment. If you notice any of the above symptoms in yourself or a loved one, contact your doctor immediately.