Cholesteatoma

Ear cholesteatoma is a pathological neoplasm consisting of dead epithelial cells, cholesterol and fats. It is formed as a result of a violation of the skin exfoliation process, when old cells are not removed, but accumulate and become denser. The growth can cause inflammation and pain, bone destruction, and ear dysfunction, including hearing loss. The main method of treatment is surgical removal of cholesteatoma.
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What is ear cholesteatoma and the mechanisms of its development

Cholesteatoma is an encapsulated neoplasm that occurs in the epithelial layers of the middle ear. In 90% of cases, its appearance is associated with chronic purulent otitis. According to statistics, such a complication occurs in 0.01% of patients with this disease.

Other reasons for the formation of cholesteatomas include:

  • Regular acute infectious processes that occur in the upper respiratory tract and ears
  • Ear injury or eardrum puncture
  • Enlarged adenoids in children
  • Anatomical features, for example, narrowing of the ear canal
  • Allergic rhinitis, accompanied by constant secretion of mucus

At risk are mainly children over 10 years old, as well as young people aged 20-30 years. The younger the patient, the more rapidly the disease progresses and causes frequent relapses.

What is ear cholesteatoma and the mechanisms of its development

Classification of cholesteatomas

There are two types of middle ear cholesteatoma:

  • Innate (true)
  • Purchased (false)

True cholesteatoma, also called “pearl tumor”, has the appearance of a smooth capsule and is formed during embryonic development. Cholesteatoma is most often localized in the temporal bone, but can also be found in other parts of the skull, including the brain.

False cholesteatomas develop against the background of prolonged inflammatory processes in the ear or after injury. Their formation is due to two mechanisms:

  • The first, associated with the penetration of the epithelium of the external auditory canal into the middle ear through defects of the eardrum
  • Second. Activated when there are problems with the Eustachian tube, leading to a decrease in pressure in the tympanic cavity, subsequent absorption and accumulation of keratin in the membrane

These processes contribute to the accumulation of dead cells and the formation of pseudotumor.

Symptoms of cholesteatoma

At an early stage, cholesteatoma usually does not cause concern to patients and is detected incidentally during examination. As cholesteatoma increases in size, discomfort and pressure on surrounding tissues and organs increase.

Other symptoms of holistoma include:

  • Headaches and dizziness
  • Insomnia
  • Deterioration of vision
  • Constant pain in the ear area
  • Purulent discharge from the ear
  • Unilateral hearing loss

Hearing loss can range from subtle to significant. Usually it is of a mixed nature due to the effect on the hearing aid.

General information about the treatment of cholesteatoma

Complications of cholesteatoma

Cholesteatoma in the ear contributes to the gradual destruction of nearby bones. It gradually expands, occupying space in the cells of the mastoid process, reaches the inner ear, destroys the labyrinth and promotes the formation of fistulas. When the cortex of the mastoid process is affected, the tumor penetrates the skin. Destruction of the bony canal of the facial nerve leads to its paresis, and damage to the sigmoid sinus causes thrombosis.

Important! As a result, the tumor reaches a significant size, forming a large cavity with processes. Outwardly, it resembles the space left after surgery.

Old formations contain cysts with toxic fluid, the rupture of which can cause aseptic meningitis or meningoencephalitis. These diseases pose a serious threat to life due to swelling of the brain.

Inflammation associated with chronic otitis is often aggravated by purulent decay of the tumor, which leads to the development of purulent labyrinthitis, meningitis, brain abscess, and otogenic sepsis.

Diagnostics of choleastomoma

CT is often used to identify ear cholecysts. The tomograph produces images in the form of slices, details anatomical features and facilitates the detection of anomalies.

In some cases, three-dimensional models are created for more accurate analysis. The main sign of cholesteatoma on CT is changes in bone structure, including destruction of the auditory ossicles.

The procedure for checking cholesteatoma on CT is painless and does not require complex preparation. Before starting the study, the patient must consent to the study. Doctors provide brief instructions and help you take the correct position on the machine table. It is important to remain still during the scan to obtain clear images.

Nuance! In rare cases, the administration of contrast may cause allergic reactions. If any discomfort occurs, you should immediately report it to medical personnel.

Before administration of a contrast agent, you must take a blood test for creatinine to assess kidney function. Patients with thyroid dysfunction or diabetes who are taking metformin should consult their doctor about having a CT scan with contrast to detect cholesteatoma in the ear.

Breastfeeding mothers should stop breastfeeding while the contrast agent is removed from the body. For young children, CT scans are performed under general anesthesia to ensure stillness and to obtain high-quality images.

Without the use of contrast, a CT scan of temporal bone cholesteatoma takes about 15 minutes. With contrast, the procedure lasts 20-35 minutes.

Important! CT scanning is contraindicated for pregnant women due to the risk to the fetus.

With cholesteatoma, CT scan reveals formations with clear boundaries that are clearly visible against the background of surrounding tissues. Most often, cholesteatoma has a round shape or is presented in the form of small nodules, ranging in size from a few millimeters to 5 centimeters. The tumor can put pressure on neighboring structures, causing their destruction, displacement of the auditory ossicles and other changes.

Conservative treatment of cholesteatoma

When small cholesteatoma of the ear is detected, a conservative approach to treatment is used. The main goal is to clean the affected area and prevent further infection. The key element is the daily use of disinfectant solutions that have the ability to dissolve protein compounds. Boric acid is also used to eliminate the inflammatory process.

Important! To speed up the healing process, your doctor may prescribe antibacterial agents in the form of tablets or ear drops. Antibiotics are selected individually, taking into account the sensitivity of the microflora found in the affected area.

Ear drops may contain not only antibacterial, but also anti-inflammatory components, as well as anesthetics to reduce pain and discomfort. Some drugs contain ciprofloxacin or neomycin. In combination with glucocorticoids (eg, dexamethasone), they reduce swelling and inflammation.

Procedures for the use of disinfectant solutions and ear drops are carried out for at least one week, and the effectiveness of therapy is regularly assessed by an otolaryngologist.

Surgical treatment

If conservative treatment does not bring the desired effect, and the tumor has reached a significant size or caused complications, urgent surgery for cholesteatoma of the ear is required.

Types of surgical treatment:

  • Cleansing surgery for cholesteatoma of the external ear
  • Surgery on the mastoid part of the bones
  • Maze Intervention
  • Access to the pyramid of the temporal bone through the labyrinth
  • Tympanoplasty, mastoidoplasty, myringoplasty

With adequate treatment and following all doctor’s recommendations, the prognosis is favorable. However, even after successful therapy, relapses are possible. Advanced stages of the disease lead to serious consequences, including deafness and intracranial complications.

Preventive measures

Effective prevention of cholesteatoma includes regular visits to an otolaryngologist for early detection and treatment of any problems affecting ear health. It is important not to ignore symptoms of infections such as pain, ear discharge or decreased hearing and to seek prompt medical attention.

In addition, proper nutrition, proper rest and stress management help strengthen the body's defenses and reduce the risk of developing inflammatory processes in the middle ear.

Our doctors

Sadikov
Ilya Sergeyevich
Head of the Clinic for Otorhinolaryngology, Otorhinolaryngologist
Tetzoeva
Zalina Muratovna
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Anastasia Andreevna
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Andrew Stanislavovich
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Maria Pavlovna
Audiologist-otorhinolaryngologist
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Galina Rustemovna
Otorhinolaryngologist, otoneurologist, audiologist
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Liliya Sergeevna
Otorhinolaryngologist, phoniatrist
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