Mean platelet volume in a complete blood count (MPV)
During its maturation, a platelet separates from its own stem cell (megakaryocyte) and then gradually, passing through several intermediate stages, becomes a mature cell.
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A decrease in the PLT volume below the norm is rare, but is sometimes observed in the case of:
- Vitamin B12 and folic acid deficiency (megaloblastic and aplastic anemia)
- Liver cirrhosis
- Myelosuppression by cytostatics and chemotherapy
- Radiation damage to bone marrow
- Splenomegaly
MPV should be assessed strictly in combination with other indicators of the CBC and coagulogram. Only in this case can this parameter have high diagnostic value and clinical role.
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About the disease
During maturation, intermediate platelet forms not only acquire the structures necessary for full functioning, but also decrease in size. Therefore, the MPV figures can be used to judge which platelets by maturity are more abundant in the vascular bed. Normally, this indicator is 7.5-12 fl (femtoliter). Its growth can have physiological significance after:
Against the background of these situations, compensatory stimulation of the release of platelet formed elements from the bone marrow occurs, followed by an increase in immature, more voluminous forms in the blood.
Pathological enlargement occurs with: