Parkinson's, Alzheimer's, Levy's

Parkinsonism is a syndrome manifested by a combination of hypokinesia with rigidity, resting tremor and postural instability, and is usually associated with damage to the basal ganglia of the brain and their connections.

Symptoms of parkinsonism:

  • hypokinesia is a mandatory sign of parkinsonism, characterized by slow movement. Hypokinesia is manifested by hypomimia (facial expressions poverty), rare flashing, micrography (handwriting becomes small), shortening the stride length, difficulty getting up from a chair, etc .;
  • rigidity - an increase in muscle tone, manifested by resistance to passive movements;
  • resting tremor - occurs in the resting limb (most often in the distal part of the arm or leg), decreases with its movement. The tremor in the hand resembles 'rolling pills' or 'counting coins'. Head tremor is not characteristic of parkinsonism;
  • postural instability - impaired ability to maintain balance when changing body position or walking.

In addition to motor disorders, the clinical picture of patients with parkinsonism often reveals: symptoms of autonomic insufficiency, cognitive and emotional-personality disorders, the assessment of which is of important differential diagnostic value.

The cause of parkinsonism can be numerous diseases that can be divided into three main groups:

  • primary (idiopathic) parkinsonism - Parkinson's disease;
  • secondary (symptomatic) parkinsonism (drug, vascular, post-traumatic, postencephalitic, toxic, parkinsonism in brain tumors and hydrocephalus);
  • parkinsonism in multisystem CNS degenerations (parkinsonism plus).

Diagnostics

The differential diagnosis of parkinsonism at the K + 31 Clinic medical center is based on characteristic complaints and a neurological examination, analysis of the effectiveness of levodopa drugs. Diagnostic difficulties usually arise only at the initial stage, when hypomimia and delayed reactions can be mistaken for manifestations of depression, and awkwardness and stiffness in the hand - for damage to the joints or manifestation of osteochondrosis. On the other hand, overdiagnosis of parkinsonism is often found, especially in patients with essential tremor or walking disorders due to normotensive hydrocephalus and discirculatory encephalopathy.

In some cases, our experts conduct additional research:

  • MSCT of the brain;
  • MSCT of cerebral vessels with contrast;
  • MSCT of the vessels of the neck with contrast;
  • MRI of the brain (including intravenous contrast);
  • MR angiography of intracranial arteries;
  • MR angiography of the neck vessels;
  • triplex scanning of extracranial (neck) and intracranial (head) sections of the brachiocephalic arteries with rotary tests;
  • clinical blood test;
  • determination of blood glucose, fibrinogen, urea, creatinine, electrolytes, cholesterol, triglycerides and lipoproteins, bilirubin, transaminase activity.

Parkinsonism Treatment

Parkinsonism treatment is mainly symptomatic. There are currently no means that are capable of demonstrably slowing the progression of the disease.

There are 6 main groups of antiparkinsonian drugs:

  • Levodopa preparations (the precursor of dopamine is Madopar, Nacom, Tidomet). In most patients with Parkinson's disease, even moderate doses of levodopa cause dramatic improvement. However, it is advisable to prescribe the drug then, as other antiparkinsonian drugs do not provide sufficient social adaptation of the patient;
  • dopamine receptor agonists (pronoran, mirapex, requip);
  • anticholinergics (cyclodol, parkopan, akineton);
  • amantadine (midantan, PC-Merz);
  • MAO B inhibitors (umex, azilekt);
  • COMT inhibitors.

Neurologists at the Clinic K + 31 Medical Center will select an individual treatment regimen for you depending on the stage, duration, form of the disease and the severity of the functional defect, patient age, presence or absence of dyskinesias and motor fluctuations, concomitant cognitive and affective disorders.

Service record



Specialists

All specialists
Mitelmayer
Tatyana Valerievna

Head of the department of neurology and psychotherapy, neurologist

Nodel
Marina Romanovna

Neurologist, consultant

Doctor of Sciences, PhD, professor

Huseynova
Kamila Timurovna

Neurologist, reflexologist

Tatarenko
Alena Igorevna

Neurologist, parkinsonologist

Burd
Sergej Georgievich

Neurologist-epileptologist

Doctor of Sciences, PhD, professor

Omarova
Sabina Magomedovna

Leading neurologist, parkinsonologist

Bogdanova
Inna Sergeevna

Neurologist, otoneurologist, somnologist

PhD