Chronic viral infections

Infectious viral diseases have a long course and latent nature of manifestation. For some reason, the body's immune response is too weak or does not recognize the infectious agent, As a result, it penetrates into organs and tissues at the cellular level and actively multiplies.

The danger of such pathologies is that they slowly kill the immune system. Early detection of infections allows treatment without complications for health, so it is important to get diagnosed after the first alarming symptoms.

Features of the course of chronic viral infections, their danger

There are certain diseases caused by viruses that always or most often take a permanent form.

Such viral infections are divided into:

  • Primary. They immediately have a chronic form and may have a long asymptomatic period. For example:
    • HIV
    • Papillomavirus.
    • Ozena.
    • Herpes.
  • Secondary. After the acute period they pass into a long-term chronic form. These are form B hepatitis, tonsillitis and others.

Secondary ones have three forms of flow:

  • With a typical picture of a chronic disease.
  • With a typical picture of a long, stable acute course.
  • With a pronounced two-phase course, including acute and chronic periods.

All chronic infectious diseases affect many organs and systems of the body. Relapses and exacerbations are frequent with periodic improvement in well-being. However, periods of remission do not lead to recovery, and the condition of patients gradually worsens. Efficiency is lost, people cannot work or care for themselves.

For those around him, a chronic person is dangerous because he remains infectious even in remission. Many viral infections can be transmitted to other people through contact or respiratory contact.

Types of pathogenic viruses and diseases

Doctors distinguish several groups of pathogenic viruses that cause infectious diseases in people of all age groups. This:

Intestinal pathogens – such as rotavirus infection.

  • Respiratory:
    • Rhinitis.
    • Bronchitis.
    • Tonsillitis.
    • Pharingitis.
    • Laryngitis.
  • Neuroinfections:
    • Meningitis.
    • Encephalitis.
  • Damaging internal organs:
    • Pneumonia.
    • Ulcerative colitis.
    • Viral hepatitis.
  • Epithelial, or diseases manifesting on the skin and mucous membranes:
    • Chickenpox.
    • Dermatitis.
    • Shingles.
    • Papillomas.
    • Warts.
  • Vascular:
    • Vasculitis.
    • Erythema.
    • Hemorrhagic fever.
  • Influencing directly the immune defense. For example, HIV.

Viral pathogens are:

  • With one or two DNA helices. These are herpes viruses, papilloma viruses, etc.
  • Only with RNA (retrovirus, poliovirus).

A large group of infectious agents penetrate the tissues of the human body forever. In this case, there is no therapeutic effect from the treatment.

The task of medical care is to minimize harm from the influence of infections and prevent the development of complications. For example, hepatitis C and B can cause cirrhosis of the liver and malignant tumors, so the patient should be under medical supervision throughout his life.

Reasons

The cause of any infection is the introduction of a viral agent into the body, into an environment favorable for development and the formation of colonies. The modes of transmission of these pathogens may vary.

Ways of infection:

  • Respiratory.
  • Hematogenous (through the bloodstream).
  • Nutritional (via the gastrointestinal tract).
  • Gender.

Several routes of infection lead to one disease. For example, viral hepatitis A is transmitted through the nutritional, or more precisely, fecal-oral route of infection. Hepatitis B and C are transmitted alimentarily through water, food, contaminated things, but can also be transmitted through blood or sexual contact. The influenza virus quickly penetrates the mucous membranes of the mouth and nose, as well as the eyes.

Are there always symptoms

The manifestation of pathology depends on the disease and degree. Viral infections often have a violent onset, and a set of signs allows the doctor to suspect the type of pathogen, which is confirmed by laboratory tests.

However, there are diseases that exist for tens of months and years without symptoms. The patient can learn about them after preventive diagnostics. Therefore, tests for these infectious pathologies are included in the list of mandatory tests during medical examinations, before operations, during pregnancy, and as part of a general examination. This:

  • Human immunodeficiency virus.
  • Viral hepatitis B, C.
  • System venereal disease syphilis.

Any malaise or intoxication syndrome should be a reason to consult a doctor. Identifying markers of viral infections in the asymptomatic stage will allow them to be treated at the initial stage and prevent infection of other people.

Diagnostics

In detecting a virus or traces of its presence in the body, only the results of laboratory diagnostics are indicative. The collection of biomaterial for research is carried out in strict compliance with diagnostic protocols. Tests can include blood, sputum, cerebrospinal fluid, skin scraping, mucosal smear, etc.

Purposes of laboratory research:

  • Identification of a pathogen or its traces.
  • Assessment of patient health indicators.
  • Analysis of the dynamics of the disease, the effectiveness of treatment.

Determination of an infectious agent takes place in one of three ways:

  • Isolation of the virus itself (direct). This is how rabies is diagnosed.
  • Inoculation of biomaterial for further isolation of the pathogen (indirect). Used in the diagnosis and study of influenza, rotavirus, adenovirus, oncogenic and neurogenic pathogens.
  • Antibody titer test (serological).

Modern laboratories must be equipped with advanced microscopes to accurately determine viral particles, intracellular inclusions, and pathogen DNA in a sample. The most modern detection method is the PCR test.

For indirect detection, a cell culture is used, into which biomaterial with the suspected virus is introduced. An increase in pathogen mass will be noticeable in samples after a certain period of time. However, researchers know that, for example, the hepatitis B virus, C virus, and some intestinal pathogens do not grow in cell culture, so other methods are used for hepatitis.

Fluctuations in IgM and IgG titers help identify the primary pathogen or determine the level of antibodies to it. PCR testing became most widely used after the coronavirus pandemic, when medical companies quickly developed rapid tests based on PCR.

To objectively assess the patient’s condition, a comprehensive diagnosis is prescribed:

  • Blood and urine tests to detect inflammation and indicators of the functioning of internal organs.
  • If hepatitis is suspected, the concentration of bilirubin and liver enzymes is examined.
  • In case of HIV, samples are taken to determine the state of immunity.

Hardware research methods can be added to laboratory diagnostics to assess the condition of internal organs - ultrasound, MRI, radiography, etc. All data is considered comprehensively and serves as an informative basis for making an accurate diagnosis and developing treatment tactics.

Treatment

Infectious viral pathologies are very difficult to treat. A virus, as a non-cellular formation, can only exist in living cells of the host organism. To do this, it penetrates inside and transfers its genome in the form of DNA or RNA to healthy cells, after which they begin to function according to the virus code.

Time does not work for the patient. To kill the virus, you need to kill these cells, which is impossible. Therefore, some chronic viral diseases are present in the human body throughout life and are considered incurable. For example, this is HIV, viral hepatitis B, C.

However, modern medicine has accumulated sufficient experience in therapy to combat such pathologies. Treatment in any case should be carried out from the moment the disease is diagnosed, which will help in many cases to be cured completely, and in case of incurable infections, to maintain the remission stage, preventing relapses and complications.

Treatment is carried out in two main areas:

  1. Etiotropic therapy neutralizes the pathogen itself. Special drugs prevent its replication, and foreign DNA ceases to act. Cells restore their original functionality, the functioning of the immune system improves.
  2. Immunomodulatory, restorative therapeutic treatment to increase the body's defenses so that it can independently fight the infectious agent.

Symptomatic treatment includes different groups of drugs:

  • Anti-inflammatory. Relief of the inflammatory process, pain.
  • Replenishing water and electrolyte losses.
  • Improving blood microcirculation, trophism, activating metabolism.
  • Vitamin and mineral complexes.

At the same time, treatment of concomitant diseases, complications, and existing chronic pathologies is performed. The doctor provides therapeutic support for the cardiovascular, endocrine, and nervous systems in elderly, weakened patients.

Features of hepatitis

In groups of viral infections with a chronic course, infectious hepatitis should be considered separately. The disease in many cases has a malignant course. It limits the functionality of the hepatobiliary system and often causes the development of cirrhosis, liver fibrosis with life-threatening consequences, and hepatocellular cancer.

What kind of disease is hepatitis

A group of diseases that cause acute, subacute, and chronic inflammation of liver cells is called hepatitis.

Hepatitis viruses come in different types, therefore they differ in their stability in the external environment and pathogenicity for the body.

Types of hepatitis

Different types of hepatitis virus cause the occurrence of diseases of different nature.

  • Hepatitis A. It occurs in an acute form, in most cases it is completely cured without complications.
  • E. It has an acute form, flu-like symptoms. Heals without consequences.
  • B, C, D, G are transmitted through the entry of the virus into the blood, which can occur during medical and cosmetic procedures, sexual intercourse, from mother to child during childbirth.

B, C hepatitis and their types, symptoms and treatment are similar. In 10-20% of their acute phases turn into chronic, which is very difficult to cure. Under the influence of viruses, the liver is destroyed, and if treatment is not started in a timely manner, the pathology ends in death.

D, G species were discovered relatively recently. Some medical researchers consider them to be a type of hepatitis C because their symptoms and course are similar.

Viral hepatitis is easier to prevent than to treat. The rules of prevention are simple, but very important for every person, and they must be followed strictly.

Prevention of chronic infections

The surest way to prevent dangerous pathologies is immunization. Unfortunately, vaccines have not been found for all viral pathogens, but there is a large group of dangerous viral diseases that can be vaccinated against:

  • Flu.
  • Coronavirus.
  • Hepatitis B.
  • Polio.
  • Measles.
  • Rubella.
  • Mumps.
  • Smallpox.

Some vaccinations are included in the national vaccination calendar of the Russian Federation; they are given to children immediately after birth. These are vaccinations against hepatitis B, polio, measles, rubella, and mumps.

Personal preventive measures:

  • Strengthening the body and immune system.
  • Hardening.
  • Good nutrition, taking vitamins.
  • Maintain good physical shape and activity.
  • Timely relief of foci of infections: caries, ulcers.
  • Compliance with the rules of personal hygiene at home and in public places: washing hands before eating and after each visit to the toilet, using personal hygiene items, keeping the house clean, drinking purified water.
  • Use of condoms during intimacy.
  • Giving up bad habits - alcoholism and drug addiction.

The multidisciplinary clinic “K+31” in Moscow provides treatment for viral infections in adults and children. Qualified doctors use treatment methods that comply with the world's best medical care protocols.

We vaccinate against COVID-19, hepatitis A, influenza, tick-borne encephalitis, etc. to prevent the occurrence of dangerous infections. Doctors will perform a pre-vaccination examination, monitor the condition after vaccinations, and draw up an individual immunization plan.

All necessary information is indicated on the K+31 website. You can also read thematic articles there, written by the clinic’s doctors, make an appointment, contact managers on questions of interest.

Service record



Specialists

All specialists
Galimova
Saida Faritovna

Gastroenterologist, hepatologist

PhD

Gasoline
Ekaterina Ilyinichna

Infectious disease physician